A Bioenhancers (bioavailability enhancers) are important substances that increase the bioefficacy of active substances. Although used in a variety of medications for patients around the world, they are also commonly found in vitamin and nutrient supplements. Bioavailability and bioefficacy are often used interchangeably but refer to two important distinctions. Bioavailability is the absorption and distribution of an active ingredient, while bioefficacy relates to how much more effective the active ingredient is.